Infectious bronchitis virus (IBV) affects poultry respiratory, renal and reproductive systems.Currently the efficacy of available live attenuated or killed vaccines against IBV has been challenged.We designed a novel IBV vaccine alternative using a Swing highly innovative platform called Self-Assembling Protein Nanoparticle (SAPN).In this vaccine,
Dynamic Fault Tree Model of Civil Aircraft Avionics Network Transmission Failure Based on Optimized Extended Fuzzy Algorithm
The avionics TRAVEL GROOMING KIT network supports high-safety-level flight operations, with the analysis of transmission failures serving as a crucial means for its safety evaluation.Due to the time-dependent nature of the failure probability in avionics networks, traditional constant and unchangeable probability values can deviate from the actual
Diversity of United States medical students by region compared to US census data
Mark M Smith,1 Steven H Rose,1 Darrell R Schroeder,2 Timothy R Long1 1Department of Anesthesiology, Mayo Clinic SUN CARE College of Medicine, Rochester, MN, USA; 2Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA Purpose: Increasing the diversity of the United States (US) physician workforce to b
Critical review and functional safety of a battery management system for large-scale lithium-ion battery pack technologies
Abstract The battery management system (BMS) is the main safeguard of a battery system for electric propulsion and machine electrification.It is tasked to ensure reliable and safe operation of battery cells connected to provide high currents at high voltage levels.In addition to effectively monitoring all the electrical parameters of a battery pack
Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins.
Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer.We suggest that the unifying theme of these events is a high level of intrinsic structural disorder, enabling fusion proteins to evade cellular surveillance mechanisms that elim